Gastro retentive drug delivery system: A review

Gastro Retentive Drug Delivery Systems (GRDDs) are an approach to prolonging gastric residence time by targeting the release of specific drugs at the top of the GIT for local or systemic effect. The Gastro Retentive Dosage Forms (GRDFs) is a very long-term time used to improve treatment with several important drugs. GRDDs are one example of a novel strategy to extending gastric residence duration, concentrating on the local or systemic effects of particular medications released in the stomach. GRDFs can provide prolonged and continuous drug release to the upper part of the Gastro Intestinal System (GIT), which greatly extends the duration of the drug release, improves the bioavailability of drugs with narrow therapeutic windows, and thus extends the dose interval and improves the patient's compliance. GRDFs enable the drug to be released longer and continuously to the upper part of GIT, thereby significantly extending the time when the drug is released and improving the bioavailability of a drug with narrow therapeutic windows, thus prolonging the dose interval and increasing patient compliance.