Asian Journal of Research in Chemistry

Despite extensive research on glycine, its solubility in binary mixtures and aqueous solutions remains underexplored from both qualitative and quantitative perspectives. This article aims to fill that gap by presenting comprehensive data on glycine’s solubility, including our own measurements and literature findings. We also report the corresponding Gibbs free energy transfer in various mixtures, including electrolytes, at different temperatures. Our results are analyzed within a thermodynamic framework, considering the physical and chemical factors that influence solubility, with the goal of improving pharmaceutical formulations.