Fabrication and characterization of solid lipid nanoparticles with etodolac for its topical delivery

Making and testing a topically applied form of etodolac made from solid lipid nanoparticles (SLNs) in order to increase the degree of transdermal penetration was the primary goal of this work. Etodolac’s topical nanolipidic gel was produced, and a number of assessment parameters were examined. SEM analysis was performed in conjunction with an in-vitro release research, size distribution test, and drug entrapment capability. Additionally, stability experiments for the prepared Etodolac SLNs were used to examine the permeation characteristics. The synthesized SLN’s zeta potential along with drug trapping effectiveness were determined to be -21 ± 8 mV to –25 ± 6 mV and 85.50 ± 1.50 percent, correspondingly. Compared to regular gel containing etodolac, etodolac-encapsulated nanogel demonstrated greater skin penetration.