Synthesis, Characterization and Biological Studies of Schiff Bases of 2,6 diamino 4-hydroxy pyrimidine with P-Methoxysalicylaldehyde and Some Transition Metal Complexes

In this research work, the heterocyclic Schiff bases ligand derived from 2,6 diamino 4-hydroxy pyrimidine with P-Methoxysalicylaldehyde (L) was synthesized. The ligand used to synthesis complexes of Cu(II), Ni(II), And Mn(II). The synthesized compounds have been characterized by FT-IR, ¹H-NMR and UV-Vis techniques for the ligands and FT-IR, UV-Vis, all reactions monitored by TLC, molar conductivity and magnetic susceptibility measurements for the corresponding complexes. The conductance measurements in DMSO showed that the Cu(II), Ni(II), And Mn(II) complex was 1:2 electrolytes respectively. The antifungal and antibacterial properties of the ligand and its complexes were tested against Fusarium moneliforme, Aspergillus niger, Penicillium chrysogenum and Staphylococcus aureus, Salmonella typhi, B. subtilis, Aspergillus flavus and Escherichia coli. The result indicated that the complexes exhibited good antifungal and antibacterial activities.