Simple Extractive Spectrophotometric Method for Determination of Imatinib Mesylate by Reactive Dyes from Pharmaceutical Dosage Form

Simple sensitive and accurate extractive spectrophotometric methods have developed for the estimation of Imatinib mesylate in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like congo red, methyl orange and eriochrome black T in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 490nm, 430nm and 500nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 4.0-24.0μg/ml, 2 -16μg/ml, 2–14μg/ml for methods 1, 2 and 3 respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of Imatinib mesylate in tablets.