Development and Evaluation of Efinaconazole Containing Potential Permeation enhancer for an enhanced Transungual Drug Delivery

The anti-fungal nail lacquer which is used in treatment of onychomycosis skin fungal disorder was focus on the disease caused and treatment by nail lacquer, onychomycosis caused by the pathogens. The success of local topical therapy for onychomycosis depends on the achievement of effective chemical concentrations into/through the human nail plate; therefore, a suitable antifungal drug must be coupled with an appropriate delivery method. The formulations were prepared by simple mixing method and analyzed for gloss, smoothness to flow, drug diffusion studies, and % drug content. Among all formulations, nail lacquer prepared with 2% oxiconazole, 5% nitrocellulose, 0.75% ethyl cellulose, 20% salicylic acid, 10% propylene glycol and 10% 2-H β-CD exhibited good drug release and drug content estimation i.e. F4 formulation. The drug release profiles were achieved 89.4% at 12 h. Nail lacquer was found to be stable after 1 month at 40±2°C.