Synthesis and Biological Screening of Some Novel Coumarin Derivatives

A new series of 7–methoxy-4-methyl-8-[5-(substituted aryl)isoxazol-3-yl]–2H–benzopyran-2-ones were synthesized by cyclisization of chalcones, 8–(2-substituted prop-2-ene)–7–methoxy–4-methyl–2H-benzopyran–2–ones with hydroxylamine hydrochloride. The chalcones were synthesized starting from 7-hydroxy–4–methyl coumarin in 4 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anti microbial and anti inflammatory activities; some of them exhibited significant activity.