Asian Journal of Research in Chemistry

  • Year: 2009
  • Volume: 2
  • Issue: 2

Method Development and Validation for estimation of Trihexyphenedyl Hydrochloride in Tablet Dosage Forms

  • Author:
  • Ashwin Patel1,, Alankar Shrivastava2, Anurekha Jain2, GK Singh3
  • Total Page Count: 4
  • DOI:
  • Page Number: 104 to 107

1Research Associate, B.A. Research House, Opposite Pushpraj Towers, Near Judges bunglows, Ahmedabad-380054

2B.R. Nahata College of Pharmacy, Mhu-Neemuch Road, Mandsaur (M.P)-458001

3Lachoo College of Science and Technology, Shastri Nagar, sector A, Jodhpur (Rajasthan)

*Corresponding Author E-mail: alankarshrivastava@gmail.com

Online published on 13 March, 2013.

Abstract

The development and validation of Trihexyphenidyl Hydrochloride was carried out by Ion pair extraction method. The estimation was measure at 410 nm. Against blank preparation and calibration curve was plotted. The Beer's Law was linear in concentration range of 2μg/ml to 18 μg/ml at 410 nm. The method developed was validated to determine its accuracy, precision and specificity. The recovery study was carried out by standard addition method.

Keywords

Trihexyphenidyl Hydrochloride, Ion pair extraction method, bromocresol green