Asian Journal of Research in Chemistry
  • Year: 2009
  • Volume: 2
  • Issue: 2

Synthesis and Evaluation of Some New Thiazolidinedione Derivatives for Their Antidiabetic Activities

  • Author:
  • Shashikant R Pattan1,, Kekare Prajact2, NS Dighe1, SB Bhawar4, Nikalje Ana3, Pati Ashwini3, MB Hole1
  • Total Page Count: 4
  • Page Number: 123 to 126

1Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar

2Department of Medicinal Chemistry, K.L.E.S.’s College of Pharmacy, Belgaum, 590 010

3Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad

4Dept. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar

*Corresponding Author E-mail: shashipattan@yahoo.com

Online published on 13 March, 2013.

Abstract

A new series of thiazolidinedione derivatives were synthesized by reacting under microwave irradiation. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All the compounds (B1-B9) were screened for antidiabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity when compared with the standard drug glibenclamide.

Keywords

Thiazolidinedione, antidiabetic activity, microwave assisted synthesis