Asian Journal of Research in Chemistry

  • Year: 2009
  • Volume: 2
  • Issue: 2

Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones

  • Author:
  • SD Firke1,, BM Firake1, RY Chaudhari2, VR Patil2
  • Total Page Count: 5
  • Page Number: 157 to 161

1KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), India

2TVES's College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), India

*Corresponding Author E-mail: sandipfirke@rediffmail.com

Online published on 13 March, 2013.

Abstract

A series of N’-[3-(aryl/alkyl substituted)-4-oxo-1, 3-thiazolidin-2-ylidene]-2-(pyridine-2-yloxy) acetohydrazides were synthesized using appropriate synthetic route. These compounds were synthesized by their analytical and spectral data. All the newly synthesized compounds were examined for their antidiabetic activity using GOD-POD method on Wistar strain rats. The acute toxicity study (LD50) values of these compounds were determined. The test compounds showed significant antidiabetic activity on evaluation.

Keywords

Thiazolidinone, Pyridine, Antidiabetic activity