Asian Journal of Research in Chemistry
  • Year: 2009
  • Volume: 2
  • Issue: 3

Potassium Ferricynide and Ferric Chloride: A Chromogenic Reagent for Estimation of Tranexamic Acid by Spectrophotometry

  • Author:
  • PB Mohite1,, RB Pandhare1, SG Khanage1, VH Bhaskar2
  • Total Page Count: 2
  • Page Number: 273 to 274

1M.E.S. College of Pharmacy, Sonai, Ahmednagar, Maharashtra-414105, India

2MP Patel College of Pharmacy, Kapadwanj, Gujarat, India

*Corresponding Author E-mail: popatmohite2006@yahoo.co.in

Online published on 13 March, 2013.

Abstract

A simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Tranexamic acid in bulk and pharmaceutical dosage formulations. The developed method is based on the formation of condensation product of drug with ferric chloride and potassium ferricynide, which shows absorbance maximum at 710 nm. The proposed method showed linearity in the range of 2–20 ug/ml. Results were statistically validated and were found to be reproducible. Recovery studies indicate that the method is accurate.

Keywords

Tranexamic acid, Ferric chloride, Potassium Ferricynide, Spectrophotometric method