Analgesic and Anti-Oxidant Activities of Certain (E)-3 Arylidene Flavanones Synthesized by One Pot Method

Objective of the study was to synthesize (E)-3-arylidene flavanones by one pot method and to screen synthesized compounds for their analgesic and anti-oxidant activities.

A set of four (E)-3 arylidene flavanones were synthesized by simple base catalyzed condensation of appropriate aryl aldehydes and 2’-hydroxy acetophenone. Analgesic activity screened by hot plate method and anti-oxidant activity evaluated by spectrophotometrically using 2,2-diphenyl-1-picrylhydrazyl (DPPH).

Results indicated that only compound I, II, and III were showed remarkable analgesic activity while compound IV didn't exhibited analgesic activity at all, but compound IV exhibited maximum anti-oxidant activity. Due to structural similarity with those of natural flavanones, all the synthesized compounds were expected to exhibit analgesic activity, but only three were found to exhibit analgesic action. But all exhibited anti-oxidant activity.