Asian Journal of Research in Chemistry
  • Year: 2009
  • Volume: 2
  • Issue: 4

Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine

  • Author:
  • P. Valentina, K. Ilango, Deepak Jain, Prerna Shukla
  • Total Page Count: 3
  • Page Number: 411 to 413

Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur -603 203

*Corresponding Author E-mail: valentina_7_srm@yahoo.com

Online published on 13 March, 2013.

Abstract

Some novel series of alkyl substituted azaphenothiazine were synthesized by condensation of 2-chloro-1-(10H-azaphenothiazin-10yl) ethanone with various amines. The synthesized compounds were confirmed by IR, 1HNMR and Mass spectroscopy. The bioavailabilities of the compounds were determined by Lipinski rule of 5 using customized software. All the compounds were screened for antimicrobial and sedative activity.

Keywords

Azaphenothiazine, Bioavailability, Antimicrobial activity, Sedative activity