Asian Journal of Research in Chemistry

  • Year: 2009
  • Volume: 2
  • Issue: 4

Synthesis and Biological Evaluation of New Benzothiazole Derivatives

  • Author:
  • Vrushali N Patil, Ameya Yadav, AS Bobade, SV Athlekar, LS Patil, Abhay Chowdhary
  • Total Page Count: 3
  • Page Number: 513 to 515

Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012

*Author E-mail: patil_vrush1@yahoo.com

Online published on 13 March, 2013.

Abstract

A series of 2-N-acetyl-[2’-(thieno substituted aryl ketone)-5’-methyl-1’,3’,4’-oxadiazolyl] benzothiazole (5a-e) have been synthesized. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords

2-amino benzothiazole, 1,3,4-oxadiazole, anti–bacterial, anti–fungal