Asian Journal of Research in Chemistry
  • Year: 2009
  • Volume: 2
  • Issue: 4

Synthesis and Antimicrobial Activity of Some Benzimidazolyl Pyrazolone Derivatives

  • Author:
  • Ameya G Yadav, Vrushali Patil, AS Bobade, SV Athlekar, LS Patil, Abhay Chowdhary
  • Total Page Count: 3
  • Page Number: 516 to 518

Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012

*Author E-mail: ameya_yadav@yahoo.com

Online published on 13 March, 2013.

Abstract

A series of 2-(1H-benzimidazol-2-ylmercapto)-N-[1,5-dimethyl-2-(substituted)phenyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl] acyl amines (5a-h) have been synthesized. These structures are determined by the elemental analyses and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords

Benzimidazole, Pyrazolone, anti–bacterial, anti–fungal