Asian Journal of Research in Chemistry

  • Year: 2009
  • Volume: 2
  • Issue: 4

Synthesis and Biological Screening of Some Novel 4-Thiazolidinone Derivatives

  • Author:
  • P Muthumani, R Meera, Pratesh , N Chidambaranathan, P Devi, Bkameswari
  • Total Page Count: 7
  • DOI:
  • Page Number: 529 to 535

K.M. College of Pharmacy, Uthangudi, Madurai – 625 107. TamilNadu, India

Abstract

A new series of substituted 4-thiazolidionones were synthesized by cyclization of Schiff's bases with thiooglycollic acid. The substituted schiff's bases were synthesized starting from substituted benzoic acid with thionyl chloride in 3 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anticonvulsant, antibacterial and anti hyperglycemic activities; some of them exhibited significant activity.

Keywords

Substituted 4-thiazolidinonnes, Anticonvulsant, Anti hyperglycemic, Anti bacterial