Synthesis and Antibacterial Evaluation of Some Novel PhenylthiazolylQuinqzolin-4(3h)-One Derivative

The present work deals with synthesis and evaluation of some novel phenylthiazole and quinazoline combination derivatives of biological interest. The reaction of acetophenone with thiourea formed 4-phenylthiazol-2-amine (I) was refluxed with N-chloroacetyl anthranillic acid (II)in the presence of K₂CO₃ in dry ethanol under anhydrous condition yields 2-chloromethyl-3-[4-(phenyl) thiazol-2-yl]-quinazolin -4(3H) one(III). The 2-chloromethyl-3-[4-(phenyl)thiazol-2-yl]quinazolin-4(3H)–one(III) and respective aromatic amines was refluxed in dry pyridine and acetic anhydride formed N-3-[4-(4–phenyl) thiazol–2–yl]-[2-(substituted amino) methyl] quinazoline–4 (3H)-one derivatives (IV).The synthesized compounds are to be screened for antibacterial activity.