1Department of Pharmaceutical Chemistry, AU college of Pharmaceutical Sciences, Andhra University, Vishakapatnam-530003, A.P, India
2Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, Andhra Pradesh India
*Corresponding Author E-mail: kkrspsp@yahoo.co.in
Online published on 13 March, 2013.
The Present work describes a simple reverse phase HPLC method for the estimation of Domperidone in bulk and pharmaceutical formulations. The estimation was carried out on Gemini, Phenomonex, C-18 (250x4.6 mm, 5μ) column using a mobile phase consisting of potassium dihydrogen phosphate buffer-Acetonitrile-Methanol (40:30:30). The eluent was monitored at 288 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.
HPLC estimation, Validation, Domperidone, Pharmaceutical formulation
