Asian Journal of Research in Chemistry
  • Year: 2010
  • Volume: 3
  • Issue: 1

Synthesis and Evaluation of Pyrrole Derivative Conjugates of Aspirin as Anti-Platelet Agents

  • Author:
  • Saurabh Chaturvedi1,, Rakesh Saini1, AN Kesari1, Awani Rai1, Neelotma Maurya1, M ShaharYar2
  • Total Page Count: 4
  • Page Number: 22 to 25

1Pranveer Singh Institute of Technology, Bhauti, Kanpur, (U.P) India, 208020

2Jamiya Hamdard University, New Delhi, India

*Corresponding Author E-mail: dearsaurabh2004@gmail.com

Online published on 13 March, 2013.

Abstract

A new series of NSAID'S in which aspirin is joined by ester linkage to pyrrole-2-carboxylic acid were synthesized and tested for anti-platelet activity. Related propyl esters of aspirin and aspirin as such were taken as references. All the compounds described here show anti-platelet activity but they do not behave as prodrugs of aspirin in blood serum.

Keywords

NSAID'S, Aspirin, Anti-Platelet Agents, Pyrrole