1East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore-560049
2Krupanidhi College of Pharmacy, Chikkabelandur, Carmelaram Post, Varthur Hobli, Bangalore-560035
3Badar Al Samaa Hospital, P.O Box-516, P C-321, Barka, Sultanate of Oman
*Corresponding Author E-mail: tathagata_d@rediffmail.com
Online published on 13 March, 2013.
A series of eight coumarino benzimidazoles have been synthesized from 4-fluro-3-nitrobenzoic acid with the help of a supporting polymer PEG5000 and with suitable reagents. These compounds have then been subjected to preliminary anti-inflammatory screening using formaline induce rat paw oedema model. All the synthesized compounds have activity comparable to indomethacin (20 mg/kg) by intraperitonial route.
Coumarino benzimidazoles, PEG5000, Anti-inflammatory activity
