Spectrophotometric Estimation of Rizatriptan Benzoate

A simple, sensitive, rapid, precise, cost effective and reproducible UV spectrophotometric method has been developed for estimation of Rizatriptan Benzoate in bulk and tablet dosage form. Rizatriptan benzoate shows maximum absorbance at 225 nm with molar absorptivity of 8.9583×10⁴ l/mol.cm. Beer's law was obeyed in the concentration range of 1–10 μg/ml. Results of analysis were validated by statistical analysis and by recovery studies. The method was validated with respect to linearity, precision, LOD, LOQ, Sandell's sensitivity and specificity. The proposed method was found to be accurate and precise for routine estimation of Rizatriptan Benzoate in bulk and tablet dosage forms.