Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel Mumbai -12
*Corresponding Author E-mail: yora_03@yahoo.com, rajeevvarma84@gmail.com
Online published on 13 March, 2013.
Heterocyclic compounds such as 5-substituted and 5,6-disubstituted-2-(N, N-dialkyl Thiocarbamido) benzimidazoles were synthesized by condensation of 5-substituted and 5,6-disubstituted-2-mercapto benzimidazoles with N, N-dialkyl carbamoyl chlorides and triethyl amine in dry 1,4-dioxane. Synthesized compounds were further screened for their biological activity and found to have good to moderate antibacterial and antifungal activity. The structures of compounds have been established on basis of their elemental analysis and spectral data (IR and NMR).
Mercapto Benzimidazole, antifungal, antibacterial, N,N-dialkyl carbamoyl chloride
