Karnataka College of Pharmacy, # 33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064
*Corresponding Author E-mail: mankar2007@rediffmail.com
Online published on 13 March, 2013.
Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1-Ulmaan ether synthesis, Step-2-Reduction of NO2, Step-3-Condensation reaction, Step-4-Nitration and evaluated for their anti-inflammatory and analgesic activities.
The compounds have been characterized on the basis of preliminary methods, spectral data and tested for antiinflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
Biphenyl ether derivatives, phenoxy methane sulphonamide derivatives, Non-sterodial antiinflammatory, analgesic drugs
