Synthesis and Antimicrobial Activity of Some New 2, 5-Disubstituted 1, 3, 4-Oxadiazoles

Ortho, meta and para-nitroaniline was treated with methyl methacrylate in the presence of acetic acid to get methyl 2-methyl-3-(o, m and p-nitroanilino)propionates which was further treated with hydrazine hydrate (99%) in the presence of absolute ethanol to get 2-methyl-3-(o, m and p-nitroanilino) propanohydrazide. The above compound was then treated with carbon disulphide in the presence of alcoholic KOH and ethanol as a solvent to get 5-{1-methyl-2-(o, m and p-nitroanilino) ethyl}-1,3,4-oxadiazole-2-thiol. These compounds were further treated with mopholine/piperidine/diethyl amine/dimethyl amine/diphenyl amine to get title compounds. The newly synthesized compounds were characterized by spectral and elemental analysis and the compounds were tested for antimicrobial activity.