Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel Mumbai -12
*Corresponding Author E-mail: yora_03@yahoo.com, rajeevvarma84@gmail.com
Online published on 13 March, 2013.
A series of benzimidazole phenylthiocarbamoyl derivatives were synthesized by condensing substituted 2-mercaptobenzimidazole with substituted benzoyl chlorides. These benzimidazole derivatives were evaluated for their antibacterial activity against Gram Positive bacteria Staphylococcus aureus (ATCC 3750) and Gram Negative bacteria Salmonella typhi (NCTC 786), as well as antifungal activity against a fungal strain Candida albicans (ATCC 10231). It was observed that the 5-naphthoxy-6-chloro benzimidazole derivatives having dichloro substitutions on the phenylthiocarbamoyl part of the molecule showed better activity than the rest.
Benzimidazole, antimicrobial, phenylthiocarbamoyl derivatives, benzoyl chloride
