New Spectrophotometric Method Applied to the Simultaneous Determination of Metoprolol Succinate and Hydrochlorthiazide

Simple, sensitive, and specific spectrophotometric methods were developed and validated for quantitation of Metoprolol succinate and Hydrochlorthiazide in tablet dosage form. A new analytical method was developed based on the simultaneous estimation of drugs in a binary mixture without previous separation. In simultaneous equation method, Metoprolol succinate and Hydrochlorthiazide were determined by using their absorptivity values at wavelength maxima, viz., 222 nm and 272 nm. The standard deviation value for the different validation parameters was found to be between 0.094 and 1.01 for simultaneous equation method. This method is simple, accurate, rapid, and they require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.