Synthesis of Some 1 -[Bis -N, N -(2 -Chloroethyl) Aminoacetyl] -3, 5-Disubstituted -1, 2 -Pyrazolines as Possible Alkylating Anticancer Agents.

A series of 1 -[Bis -N, N-(2-Chloroethyl) aminoacetyl] -3,5 -disubstituted -1,2 pyrazolines have been synthesized by the treatment of 1 -[Bis -N, N -(2-hydroxyethyl) aminoacetyl] -3,5 -disubstituted -1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, ¹H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.