Advance in Mass Ionization Techniques

Mass spectrometry is the most sensitive and accurate technique for determining the molecular mass of the compound and its elemental composition. But most important thing on which whole mass spectrometry depends is ionization of the compounds. In this review work we have discussed about Gas-Phase Ionization, Field Desorption and Ionization, Particle Bombardment, Atmospheric Pressure Ionization, Laser Desorption, Inductively Coupled Plasma, High pressure ionization. These are the main principles for the ionization of the compounds, and based on this we have tried to describe twelve techniques with their applications in the pharmaceutical industries. Now-a-days the use of mass spectrometry from just identification of the compounds turns towards the DNA-RNA sequencing and also for the amino acid sequencing.