Asian Journal of Research in Chemistry
  • Year: 2010
  • Volume: 3
  • Issue: 3

Method Development and Validation for Estimation of Quetiapine Fumarate by RP-HPLC

  • Author:
  • Ashish Baldi, Ashutosh Kumar Patidar, Jyotsana Sanadya
  • Total Page Count: 4
  • Page Number: 604 to 607

College of Pharmacy, Shri R.M.S. Institute of Science and Technology, Bhanpura, Dist. Mandsaur, (M. P.) 458775, India

*Corresponding Author E-mail: baldiashish@gmail.com

Online published on 13 March, 2013.

Abstract

A precise and accurate reverse phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for estimation of quetiapine fumarate. The mobile phase consisted of methanol: water: acetonitrile (50: 40:10) was used at a flow rate of 1 ml/min and pH value of 7.0, adjusted with orthophosphosphoric acid. The detection was carried out at a wavelength of 251 nm. The developed method was found to be in accordance with ICH guidelines with respect to accuracy, precision, reproducibility, linearity and specificity.

Keywords

Quetiapine fumarate, RP-HPLC, Validation