College of Pharmacy, Shri R.M.S. Institute of Science and Technology, Bhanpura, Dist. Mandsaur, (M. P.) 458775, India
*Corresponding Author E-mail: baldiashish@gmail.com
Online published on 13 March, 2013.
A precise and accurate reverse phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for estimation of quetiapine fumarate. The mobile phase consisted of methanol: water: acetonitrile (50: 40:10) was used at a flow rate of 1 ml/min and pH value of 7.0, adjusted with orthophosphosphoric acid. The detection was carried out at a wavelength of 251 nm. The developed method was found to be in accordance with ICH guidelines with respect to accuracy, precision, reproducibility, linearity and specificity.
Quetiapine fumarate, RP-HPLC, Validation
