1Department of Chemistry PG Centre, Bellary, Gulbarga University, Gulbarga, Karnataka, India
2Department of Chemistry, G M Institute of Technology, Davangere, Karnataka, India
*Corresponding Author E-mail: virupaxb@gmail.com
**E-mail: lathamschem97@gmail.com
Online published on 13 March, 2013.
Simple and rapid spectrophotometric method for the determination of Pitavastatin is described. The method is based on the reaction of H2O2 with Pitavastatin and its reaction with potassium iodide to liberate iodine. The liberated iodine bleaches the Blue colored Toluidine blue and is measured at 630 nm. The Beer's law is obeyed in the range of 19.0 – 132.0 μg ml−1 for Pitavastatin using TB as reagent. The molar absorptivity, detection limit and quantization limit were also calculated. The optimum reaction conditions and other analytical parameters were evaluated. The statistical evaluation of the method is examined by determining intra-day and inter-day precision. The proposed method is simple, accurate and easy to apply for routine use.
Spectophotometry, Pitavastatin, Toluidine Blue
