1Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002, Uttar Pradesh, India
2Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India
*Corresponding Author E-mail: rverma.rajeev@gmail.com
Online published on 13 March, 2013.
A series of indole fused triazine derivatives have been synthesized and characterized by elemental and spectral analysis, further the compounds have been screened for antimicrobial activity against ten strains of Gram (+) and Gram (−) bacteria. Compound 5a was found to be most active in the series against E. faecalis ATCC29212 with MIC 12.5 μg/mL. From the antimicrobial screening result, it was observed that the newly synthesized compounds 5a, 5i and 5j showed good antimicrobial activity compared with standard sulphamethoxazole.
Triazine, antibacterial activity, MIC value, indole nucleus
