4-Thiazolidinones as Calcium Antagonist: Synthesis and Pharmacological Screening

Various derivatives of 4-thaizolidinones were synthesized by reacting Schiff bases with thioglycollic acid. These alcoholic groups were further oxidized to get the carboxylic acid derivatives. The compounds were purified using flash chromatography and were characterized by physical, chemical and elemental analysis. The compounds were screened for calcium antagonistic activity on albino rats by using Biopack data acquisition system. Some compounds showed comparable activity with standard drug Diltiazem.