Synthesis of 2-Imino-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-5-Arylidene-1, 3-Thiazol-4-One as Potent CNS Depressant and Antimicrobial Agents.

2-Imino-3-(5-aryl-1, 3, 4-thiadiazolyl)-1,3-thiazol-4-one (E) have been synthesized from Arylaldehyde and Thiosemicarbazide. Condensation of the Iminothiazol-4-one with different substituted aromatic aldehyde and fused sodium acetate in glacial acetic acid to get 2-Imino-5-(4-substituted arylidene)-3-(5-aryl-1, 3, 4-thiadiazol-2-yl) -1,3-thiazol-4-one (F1-7). The structures of the synthesized compounds were conformed on the basis of spectral data. The compounds have been screened for their possible CNS depressant and anti microbial activities. Among the synthesized compounds F1, F2, F4 and F7 showed significant CNS depressant activity and compounds F1, F2, F4 and F6 showed moderate antimicrobial activity.