Asian Journal of Research in Chemistry
  • Year: 2010
  • Volume: 3
  • Issue: 3

Spectrophotometric Estimation of Tramadol Hydrochloride in Bulk and Tablet Dosage Form

  • Author:
  • S.R. Bavaskar, A.D. Agrawal, Y.S. Agrawal, A.N. Amrutkar, Niraj L. Badhe, P.S. Kawatikwar
  • Total Page Count: 2
  • Page Number: 714 to 715

Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jammer Dist-Jalgaon 424206

*Corresponding Author E-mail: bavaskarsunilkumar@gmail.com

Online published on 13 March, 2013.

Abstract

A simple, sensitive, accurate and precise UV Spectrophotometric method has been developed for quantitative determination of Tramadol Hydrochloride in bulk and tablet formulations. The UV-spectrum was scanned between 220 to 400 nm and 270.5 nm was selected as maximum wavelength for absorption. Tramadol shows molar absorptivity of 1.771×104l/mol/cm and Sandell's sensitivity 0.16927mcg/Sq.cm/0.001-absorbance units. Beer's law was obeyed in the concentration range of 15–170 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords

Tramadol hydrochloride, tablet, ultraviolet spectrophotometric estimation