Efficient One Pot Green Synthesis of 2-Aryl/Heteryl-Benzothiazoles as Anti-inflammatory Agents

In the present investigation rapid and efficient cyclo-condensation of 2-aminothiophenol with aldehydes under microwave irradiation in solvent free conditions in presence of catalyst zirconium oxy chloride was carried out to afford the corresponding 2-substituted benzothiazoles 3a. This one pot, neat green synthesis is obtained in high purity, good yield of products and in short span of time in presence of ecofriendly catalyst under microwave irradiation. The structures of all the products are characterized by spectral analysis. All the synthesized products are screened for their anti-inflammatory activity and have shown promising anti-inflammatory activity.