Spectrophotometric Determination of Atorvastatin in Pharmaceutical Formulations

Rapid, simple and sensitive spectrophotometric methods (A&B) have been developed for the determination of Atorvastatin (ATN) in pharmaceutical bulk and tablet dosage form. Method A is based on the reaction of ATN with 3-methyl-2-benzothiazolinone hydrazone and ferric chloride to form green colored chromogen. Method B is based on the formation of wine red colored chromogen with 1,2-naphthaquinone-4-sulphonate and NaOH. The absorbances of the chromogens were measured at their respective wavelengths of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.