Synthesis and Biological Evaluation of New Pyridine Derivatives

The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K₂CO₃ followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS₂ and KOH cyclized to give (IV) which on reaction with different acid chloride form 2-(3-pyridoxymethyl)-5-(4-substitutedphenyl)-1,3,4-triazole. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).