Asian Journal of Research in Chemistry
  • Year: 2010
  • Volume: 3
  • Issue: 4

New UV-Visible Spectrophotometric Methods for the Determination of Tadalafil in Bulk and Pharmaceutical Formulation

  • Author:
  • G.V.H. Raju, S. Ganapathy, D.G. Sankar, P.Y. Naidu
  • Total Page Count: 3
  • Page Number: 958 to 960

Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003

*Corresponding Author E-mail: gadepalli_raj@yahoo.com

Online published on 13 March, 2013.

Abstract

A simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Tadalafil (TADL) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Tadalafil (TADL) with Folin-Ciocalteu reagent in presence of 4% NaOH Solution. Method B is based on the formation of colored species on treatment of Tadalafil (TADL) with Sodium nitroprusside and Hydroxyl amine. Method C represents UV Spectrophotometric determination of Tadalafil (TADL) and its dosage forms in pH 2.9Buffer : Acetonitrile (40:60v/v) at 285nm.