Synthesis and Cytotoxic Activity of New Indole Derivatives

Some new (Napthalen-1-yloxyl/2-yloxy) -acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.