Synthesis of Thiophene Compounds of Pharmacological Interest

An attempt was made to synthesize new substituted thiophenes as anti-inflammatory agent, adapting Gewald reaction. A new series of compounds were synthesized from 2-amino-N-(3-chloro-4-fluorophenyl) thiophene-3-carboxamide and the required aryl aldehydes to yield seven new Schiff bases. The structures of new compounds were established on the basis of spectral and elemental analysis. The title compound were screened for anti-inflammatory, anti-bacterial and anti-oxidant activity by serum albumin protein denaturation method, agar diffusion method and ferric ion reduction method respectively. Most of the compounds have shown promising activity.