K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada -520010, Andhra Pradesh, India
*Corresponding Author E-mail: ali.shaiba@gmail.com
Online published on 6 March, 2013.
Two simple and sensitive spectrophotometric methods have been developed for the estimation of Milnacipran in pure and pharmaceutical dosage forms. Method A is based on oxidative coupling of the drug with folin-ciocaltaeu reagent (F.C.reagent) λmax780nm. Method B is based on oxidation followed by complex formation when the drug reacts with P-Methylamino phenolsulphate (Metol reagent) λmax 540nm. The absorbance of the colored species is measured against the corresponding reagent blank. These methods have been statistically evaluated and found to be precise and accurate.
