Synthesis and Antimicrobial Activities of Thiazolo [3, 2-a] Pyrimidine Derivatives

In the present study a novel thiazolo [3,2-a] pyrimidines were synthesized by one pot multicomponent cyclocondensation of 2-amino-4-phenyl thiazole, benzoyl acetone and various substituted aromatic aldehydes on solid support under microwave irradiations. The 2-amino-4-phenyl thiazole was synthesized from acetophenone. Some of the compounds were screened for anti-bacterial (Staphylococcus aureus, Staphylococcus aureus (MRSA), Staphylococcus pyogenes) and antifungal (Aspergillus niger, Neurospora crassa) activities by Agar Diffusion method.