Synthesis of Aminoacetylcoumarins and Aminoacetylnaphthocoumarins and their Antibacterial activity study

Knoevenagel condensation of 2-hydroxy-1-naphthaldehyde with ethylacetoacetate gave 2-acetyl-benzo[flchromen-3-one (1). Bromination of (1) with bromine in chloroform gave 2-(2-bromoacetyl)-benzo[flchromen-3-one (2), which on condensation with different primary aromatic amines gave corresponding amino acetyl derivatives (3a-c). Similar series of reactions were carried out on salicylaldehyde and resorcaldehyde, which gave corresponding 3-aminoacetyl coumarin and 7-hydroxy-3-aminoacetyl coumarin derivatives. Screening of these compounds for antibacterial activity against Staphylococus aureus (Gram +ve), Micrococus leuteus (Gram +ve) and DH5α-Escherichia coli (Gram -ve) show good antibacterial activity.