Synthesis, Characterization and CNS Depressant Activity of Some Schiff Bases of 2-Amino-4-(4-Chlorophenyl)Thiophene-3carboxamide

2-amino-4-(4-chlorophenyl)thiophene-3carboxamide was synthesized using versatile Gewald reaction conditions started with the preparation of acetamide, which was carried out by cold condensation of aniline and ethylcynoacetate, which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4-chlorophenyl)thiophene-3carboxamide. Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases (SBJ-Ia-l). The compounds were characterized by IR, 1H NMR and Mass spectral data and screened for CNS depressant activity.