Synthesis, Characterization and Biological Evaluation of Novel 1,3,4-Oxadiazole Derivatives of 3-(2-napthoyl) propionic acid

An easy access to a series of 1,3,4-oxadiazoles bearing a 1-(naphthalen-2-yl)propan-1-one side chain in the 4-position is described. These compounds were obtained starting from commercially available Naphthalene and aromatic acids. The work involves Friedal craft acylation reaction of hydrocarbons i.e. Naphthalene that result in formation of Aroyl propanoic acid and finally this Aroyl propanoic acid is condensed with different aromatic hydrazides and result in formation of 1,3,4-oxadiazoles. The resulted compounds were screened for their biological activity.