Asian Journal of Research in Chemistry
  • Year: 2011
  • Volume: 4
  • Issue: 12

Synthesis of New Indoline-2-Ones and Their Microbial Activity

  • Author:
  • Freddy H. Havaldar, Azadkumar S. Sharma, Peter Roni F. Pinto
  • Total Page Count: 4
  • Page Number: 1840 to 1843

Nadkarny-Sacasa Research Laboratory Department of Chemistry, St. Xavier's College, Mumbai -400 001

*Corresponding Author E-mail: azadsharma83@gmail.com

Online published on 6 March, 2013.

Abstract

The acid hydrazides (I and IV) were condensed with indole-2,3-dione in ethanol to yield hydrazono-indolin-2-ones (II and V) which on aminomethylation with formaldehyde and different amines furnished 1-(substituted aminomethyl)hydrazono-indolin-2-ones (IIIa-e and VIa-e). The structures of the newly synthesized compounds have been confirmed by IR, 1H NMR and Mass spectra. These compounds have shown promising biological activity.

Keywords

Synthesis, Mannich bases, biological activity, spectral data