Synthesis of Some New 5-(4-(Phenylamino) Phenyl)-1, 3, 4-Thiadiazol-2- Amine Derivatives as Potent Antifungal Agents.

Recently a series of 5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-amine derivatives were synthesized and their pharmacologically evaluated for antifungal activity. The purpose of this study was to evaluate the effects of the title compounds on fungal activity by varying the substituted in the1,3,4-thiadiazole moiety. All compounds of this series showed promising antifungal activity. It was found that some of these compounds possess marked antifungal properties comparable in efficiency to the reference drug Flukanazole. In present study the structures of compounds were confirmed by IR, UV ¹H NMR and elemental analysis.