Synthesis and Biological Evaluation of New Chalcone Analogs

The inevitable consequence of the widespread use of antimicrobial agents has been the emergence of antibioticresistant pathogens, fueling an ever-increasing need for new drugs. In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of bromo and chloro acetophenone with appropriate aromatic aldehydes in the presence of aqueous solution of sodium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by their physical constants, TLC, IR and NMR spectroscopy. Further all the synthesized compounds were successfully evaluated for their antibacterial and antifungal activities by cup-plate method.