Asian Journal of Research in Chemistry
  • Year: 2011
  • Volume: 4
  • Issue: 2

Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole

  • Author:
  • Alok Pandey1,, Shekhar Verma2, Ravindra Dhar Dubey2, Dhansay Dewangan1, Vidyanand Patel2, Keshav Deshmukh2
  • Total Page Count: 4
  • Page Number: 278 to 281

1Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52, Tamilnandu, India

2Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur -492101 (C.G.), India

*Corresponding Author E-mail: aalokpandey444@gmail.com

Online published on 6 March, 2013.

Abstract

Schiff Bases of 2-amino-5-aryl-1, 3, 4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1, 3, 4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against Swiss albino mice, anti-inflammatory activity against Wister albino rats.

Keywords

Schiff base, 1,3,4-thiadiazole, Analgesic, Anti-inflammatory activity