Asian Journal of Research in Chemistry
  • Year: 2011
  • Volume: 4
  • Issue: 2

Synthesis of Some New 3-(4-Phthalimidophenyl)-5-(Substituted Phenyl) 4-Isoxazoline Derivatives with Analgesic and Anti-Inflammatory Activities.

  • Author:
  • Deepak Lande, Meenakshi Deodhar, Ashok Bhosle, Ganesh Bhawal
  • Total Page Count: 6
  • Page Number: 316 to 321

Dep. of Pharmaceutical Chemistry, SGRS College of Pharmacy, Saswad, Pune, Maharashtra-412301, India

*Corresponding Author E-mail: deepak_lande@rediffmail.com

Online published on 6 March, 2013.

Abstract

The derivatives of 3-(4-phthalimidophenyl)-5-(substituted-phenyl)-4-isoxazoline were synthesized, which were screened for their analgesic and anti-inflammatory activity in test animals. The analgesic activity of all compounds were found to be higher than their anti-inflammatory activity, Compounds 3b, 3e, 3h and 3l were found to be more active among the synthesized compounds.

Keywords

Thalidomide, Isoxazoline, Anti-inflammatory, Hydroxylamine hydrochloride